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复方磺胺增效剂(TMP加SMZ)广泛用于肾损害病人。但有人报告此药可引起肾脏疾病病人的肾功能恶化,认为血浆肌酐超过2毫克/100毫升者不应使用。作者临床经验不支持上述观点,因而研究此药对肾损害病人肾功能的影响。观察对象:为不同程度肾功能损害伴呼吸道或泌尿道感染病人20例,其中男8例,女12例,年龄26～80岁,应用复方磺胺增效剂(每片含TMP 80毫克和SMZ 400毫克)治疗10天,剂量按血浆肌酐含量调整(见表)。在治疗前、治疗时(每天)和治疗后均测定血尿素和血浆肌酐。结果:17例在治疗时或治疗后
Compound sulfonamide synergist (TMP plus SMZ) is widely used in patients with kidney damage. However, it was reported that this medicine can cause renal failure in patients with renal disease deterioration, that more than 2 mg / 100 ml of plasma creatinine should not be used. The author’s clinical experience does not support the above point of view, thus studying the effect of this drug on renal function in patients with renal impairment. Subjects: 20 patients with varying degrees of renal dysfunction with respiratory or urinary tract infections, including 8 males and 12 females, aged 26 to 80 years, the application of sulfamethoxazole synergist (each containing TMP 80 mg and SMZ 400 Mg) for 10 days, the dose adjusted according to the content of plasma creatinine (see table). Blood urea and plasma creatinine were measured before treatment, during treatment (daily), and after treatment. Results: 17 cases were treated or after treatment