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肝内胆管细胞癌（ICC）起源于二级胆管及其分支上皮细胞，是恶性程度较高和预后较差的肝脏恶性肿瘤之一。淋巴结转移是严重影响ICC患者预后的因素。近年来，许多研究发现乙型肝炎病毒（HBV）是ICC发生的危险因素之一，HBV相关ICC具有类似与肝细胞癌的临床病理表现。另外，新近研究表明HBV阳性ICC患者术后预后优于HBV阴性患者，且HBV阳性ICC患者淋巴结转移率较低。因此，进一步探索HBV在ICC的发生和预后中的作用有着重要的临床意义。“,”Intrahepatic cholangiocarcinoma (ICC) arising from the epithelial cells of the second order bile ducts and their branches, is one of the liver cancers with high degree of malignancy and poor prognosis. Lymph node metastasis is the most important factor affecting the prognosis of ICC patients. Recently, many studies indicated that hepatitis B virus (HBV) is an independent risk factor for ICC, and the clinical manifestations in patients with HBV-associated ICC are similar to those with hepatocellular carcinoma. Further, the latest studies demonstrated that the prognosis in HBV-positive ICC patients is better than that in HBV-negative patients, and HBV-positive ICC patients have a relatively low rate of lymph node metastasis. hTus, further insight into the actions of HBV on the pathogenesis and outcomes of ICC is of great clinical signiifcance.