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目的 探讨致心律失常性右心室心肌病 (arrhythmogenicrightventricularcardiomyopathy ,ARVC)危重患者、家系中无症状患者及家系中可疑患者的QRS及QT离散度的存在规律。方法 按欧洲心脏病学会 (ESC)的诊断标准 ,选择有室性心动过速、晕厥或心脏骤停 (cardiacarrest)史的ARVC患者 2 5例为危重组 ,家系调查发现的家系中无明显症状的ARVC患者 16例为无症状组 ,家系中高度怀疑为ARVC但尚未达到诊断标准的 18例为可疑组 ,正常对照组为 14例。同步记录标准 12导联心电图。测量每个导联QRS时限 ,记录 12导联中的QRS时限最大值 (QRSm ,最长的 1个QRS值 )、QRS离散度 (QRSd ,12导联中最长的 1个QRS值减最短的 1个QRS值 )及QRS时限平均值 (QRSa)。测量每个导联QT间期 ,记录 12导联中的QT最大值 (QTm ,最长的 1个QT间期 )、QT平均值 (QTa)、QT离散度 (QTd ,导联中最长的 1个QT值减最短的 1个QT值 )、校正QTd(QTcd)及校正QTm(QTcm)。比较各组各指标的差异。结果 可疑组的年龄低于对照组、危重组与无症状组。 4组之间QRSd差异无显著性。QTd在危重组为 (6 9 6± 4 1)ms,在无症状组为 (77 3± 5 7)ms均显著高于对照组 (5 5 4±6 3)ms(P均为 0 0 0 3) ;危重组与无症状组差异无显著性。QRSm、QRSa、QTa、QTcd、QT
Objective To investigate the existence of QRS and QT dispersion in patients with asymptomatic arrhythmogenic right ventricular cardiomyopathy (ARVC), asymptomatic families and suspicious families in pedigrees. Methods Twenty-five ARVC patients with a history of ventricular tachycardia, syncope or cardiac arrest were selected as critically ill according to the diagnostic criteria of the European Society of Cardiology (ESC). There were no obvious symptoms in the pedigrees of the pedigree survey Sixteen ARVC patients were asymptomatic, 18 were suspicious in the pedigrees who were highly suspected of having ARVC but not yet reached the diagnostic criteria, and 14 in the normal control group. Simultaneous recording of standard 12-lead ECG. The QRS duration was measured for each lead, the maximum QRS duration (QRSm, the longest QRS value), the QRS dispersion (QRSd, the longest QRS value in the 12 lead minus the shortest 1 QRS value) and QRS duration (QRSa). The QT interval was measured for each lead, and the maximum QT (QTm, longest QT interval), QTa, QTd (QTd, the longest 1 QT value minus the shortest 1 QT value), correct QTd (QTcd), and correct QTm (QTcm). Compare the differences of each index of each group. Results The age of the suspicious group was lower than that of the control group, the critically ill group and the asymptomatic group. There was no significant difference in QRSd between the 4 groups. QTd was significantly higher in the critically ill group than in the control group (69 ± 4 1) ms and in the asymptomatic group (77 ± 5 ± 7) ms compared with the control group (54 ± 6 3) ms (P = 0 0 0 3); no significant difference between critically ill and asymptomatic groups. QRSm, QRSa, QTa, QTcd, QT