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目的:分析儿童系统性红斑狼疮(SLE)早期诊断的临床表现及实验室检查特点。方法:选取肇庆市第一人民医院收治的68例符合SLE的儿童,比较患儿的首发症状、临床表现及实验室检查资料,研究儿童SLE早期诊断依据。结果:皮肤黏膜损害与蝶形红斑患者中女性较男性高发,差异具有统计学意义(P<0.05)。女性患儿的ANA阳性率高于男性,男性患儿的抗SSB抗体阳性率高于女性,差异具有统计学意义(P<0.05)。结论:儿童SLE起病的临床表现多样,实验室检验结果多提示血液系统、肾脏功能损害,临床表现及实验室检查缺乏特异性,需要综合诊断,减少漏诊误诊。
Objective: To analyze the clinical manifestations and laboratory features of early diagnosis of systemic lupus erythematosus (SLE) in children. Methods: 68 cases of children with SLE admitted to First People’s Hospital of Zhaoqing were selected to compare the initial symptoms, clinical manifestations and laboratory tests in children, and to study the basis of early diagnosis of SLE in children. Results: The incidence of mucocutaneous lesions in women with butterfly erythema was higher than that in males. The difference was statistically significant (P <0.05). The positive rate of ANA in female children was higher than that in men, and the positive rate of anti-SSB antibody in male children was higher than that in women. The difference was statistically significant (P <0.05). Conclusion: There are many clinical manifestations of SLE onset in children. Most laboratory tests suggest that the blood system, renal dysfunction, clinical manifestations and laboratory tests are not specific and need comprehensive diagnosis to reduce the misdiagnosis of missed diagnosis.