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目的 :研究一氧化氮 (NO)对妊高征发病的影响。方法 :用一氧化氮合酶 (NOS)抑制剂L 硝基 精氨酸甲酯 (L NAME)抑制孕鼠体内NO合成 ,观察血压、尿蛋白、子鼠体重、血NO、血内皮素 (ET 1)水平变化 ;同时观察NO供体硝酸甘油释放NO ,对L NAME作用的影响。结果 :模型组孕鼠较对照组血压升高 ,尿蛋白增多 ,子鼠体重下降 ,血NO水平下降 ,血ET 1水平上升 (均 P<0 0 1) ;治疗组孕鼠较模型组血压下降 ,尿蛋白减少 ,子鼠体重增加 ,血NO水平上升 ,血ET 1水平下降 (均P <0 0 1)。结论 :NO水平下降是妊高征发病的因素之一。
Objective: To study the effect of nitric oxide (NO) on the pathogenesis of PIH. Methods: Nitric oxide synthase (NOS) inhibitor L NAME was used to inhibit NO synthesis in pregnant rats. Blood pressure, urinary protein, body weight, serum NO, endothelin (ET) 1) level changes; at the same time NO donor nitroglycerin release of NO, the role of L NAME. Results: Compared with the control group, the blood pressure, the proteinuria, the weight of the offspring, the level of blood NO and the level of ET1 in the model group were significantly higher than those in the control group (all P <0.01) , Decreased urinary protein, weight gain in the offspring, elevated blood levels of NO, and decreased ET 1 levels (all P <0.01). Conclusion: The decline of NO level is one of the factors of PIH.