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目的:观察中西医结合疗法对精索静脉曲张伴不育患者术后精液质量及性激素水平的影响。方法:选取腹腔镜治疗的精索静脉曲张伴不育患者72例,随机分为治疗组与对照组各36例;对照组在全麻下行腹腔镜下精索静脉高位结扎术,术后予以维生素E胶囊口服;治疗组在对照组的基础上加用温肾益精方治疗,2组均治疗3月。观察2组治疗前后精液质量及性激素睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)指标的变化情况。结果:2组患者精子密度、精子活力较治疗前提高,精子畸形率较前降低,差异均有统计学意义(P<0.05,P<0.01);且治疗组上述指标改善较对照组更显著(P<0.05)。治疗后2组患者T水平明显升高,LH和FSH水平降低,差异均有统计学意义(P<0.05,P<0.01);且治疗组上述指标改善较对照组更显著(P<0.05)。结论:中西医结合治疗精索静脉曲张伴不育术后患者,能改善精液质量,提高T水平,降低LH和FSH水平,从而改善生精功能。
Objective: To observe the effect of integrated traditional Chinese and western medicine on postoperative sperm quality and sex hormone levels in patients with infertility. Methods: Seventy-two patients with infertility and varicocele treated with laparoscopy were randomly divided into treatment group (36 cases) and control group (36 cases). In the control group, laparoscopic varicocele was performed under general anesthesia. After operation, vitamins E capsule orally; the treatment group was treated with Wenshen Yijing Decoction on the basis of the control group, and both groups were treated for 3 months. The changes of semen quality, sex hormone testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were observed before and after treatment in two groups. Results: The sperm density and sperm motility in two groups were higher than those before treatment, and the sperm deformity rate was lower than before (P <0.05, P <0.01). The improvement of the above parameters in the treatment group was more significant than that in the control group P <0.05). After treatment, the levels of T were significantly increased and the levels of LH and FSH decreased in both groups (P <0.05, P <0.01). The improvement of the above parameters in the treatment group was more significant than that in the control group (P <0.05). Conclusion: Integrative treatment of varicocele patients with infertility can improve the quality of semen, improve the T level, reduce the levels of LH and FSH, so as to improve the function of spermatogenesis.