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对３２例同组病例胃癌组织中雌激素受体（ＥＲ）及患者手术前后外周血ＮＫ细胞活性、Ｔ细胞亚群的变化进行了检测。结果：①ＥＲ阳性率为３１．３％，男女之间差异无显著性，但ＥＲ阳性组中粘液癌、低分化癌或未分化癌明显高于ＥＲ阴性组；②进展期胃癌息者ＮＫ细胞活性及明显降低，而明显增加，比值下降，上述变化在ＥＲ阳性组更为明显；③术后１个月ＮＫ细胞活性及Ｔ细胞亚群值均有一定程度恢复，但ＥＲ阳性组恢复的程度较低。提示进展期胃癌患者细胞免疫功能明显障碍，而ＥＲ阳性者更为显著。
The changes of NK cell activity and T lymphocyte subsets in peripheral blood of estrogen receptor (ER) and patients before and after surgery were detected in 32 cases of the same group. Results: 1ER positive rate was 31.3%, there was no significant difference between men and women, but ER positive group was significantly higher than ER negative group in mucinous, poorly differentiated or undifferentiated cancer; 2 NK cell activity in advanced gastric cancer. Significantly decreased, but significantly increased, the ratio decreased, the above changes in the ER positive group is more obvious; 3 NK cell activity and T cell subsets values were recovered to a certain extent after 1 month, but the degree of recovery of the ER positive group was more low. It is suggested that the cellular immune function is significantly impaired in patients with advanced gastric cancer, while the ER positive is more significant.