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目的 研究K ras基因突变和CA19 9联合检测在胰腺癌诊断中的作用。 方法 选择同期的 15例胰腺癌和 33非胰腺癌病人 ,同时行外周血K ras基因突变和CA19 9的检测 ,利用统计学方法进行数据分析。 结果 外周血K ras基因突变和CA19 9联合检测诊断胰腺癌的敏感性、特异性分别为 6 6 6 7%和 97% ,研究组和对照组之间差异具有显著性意义 (P =0 0 0 1)。 结论 外周血K ras基因突变和CA19 9的联合检测显著提高了胰腺癌诊断的特异性 ,弥补了单一K ras基因突变和CA19 9检测的不足 ,可用于胰腺癌的辅助诊断。
Objective To investigate the role of K ras gene mutation and CA19 9 in the diagnosis of pancreatic cancer. Methods 15 cases of pancreatic cancer and 33 non-pancreatic cancer patients were selected in the same period. At the same time, K ras gene mutation in peripheral blood and CA19 9 were detected, and the data were analyzed by statistical methods. Results The sensitivity and specificity of K ras gene mutation in peripheral blood and CA19 9 combined detection in diagnosis of pancreatic cancer were 66.67% and 97%, respectively. There was significant difference between study group and control group (P = 0 0 0 1). Conclusion The combined detection of K ras gene mutation and CA19 9 in peripheral blood significantly improves the specificity of diagnosis of pancreatic cancer and makes up for the deficiency of single K ras gene mutation and CA19 9 detection. It can be used in the diagnosis of pancreatic cancer.