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近年来,随着感染菌群的变迁,免疫功能障碍病人的增多,社会的老龄化,器官移植以及诊治技术的提高和改进,使感染性疾病变得复杂和难治,细菌耐药已成为突出的全球性问题,给临床医生治疗重危病人感染带来许多棘手难题。另外,随着抗生素在临床上日益广泛应用及不合理滥用,使抗菌药物不良反应也随之增加,所谈及不良反应的含义包括副作用、毒性反应、变态反应、三致作用、后遗反应等。
In recent years, bacterial resistance has become prominent with the change of infectious flora, the increase of immunocompromised patients, the aging of society, the improvement and improvement of organ transplantation and diagnosis and treatment techniques, and the complicated and refractory infectious diseases Global issues, to clinicians treat many critically ill patients with many difficult problems. In addition, with the increasingly widespread clinical use of antibiotics and unreasonable abuse, so that adverse reactions of antimicrobial drugs also increased, the meaning of the adverse reactions mentioned, including side effects, toxicity, allergies, mitigation, reaction and so on .