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目的:考察盐酸雷尼替丁与替硝唑葡萄糖注射液的配伍稳定性。方法:按临床常用剂量将雷尼替丁注射液与替硝唑葡萄糖注射液配伍,观察配伍液在0～24h内的物理变化(外观、pH);采用双波长分光光度法犤1犦不经分离直接测定盐酸雷尼替丁和替硝唑葡萄糖注射液配伍前后的含量变化。结果:在室温条件下,0～24h内其外观、pH无明显变化;替硝唑含量几乎无变化,盐酸雷尼替丁的含量在24h内有下降趋势,但不超过10%。结论:盐酸雷尼替丁与替硝唑葡萄糖注射液可以配伍使用。
Objective: To investigate the compatibility of ranitidine hydrochloride and tinidazole dextrose injection stability. Methods: The combination of ranitidine and tinidazole dextrose injection according to the clinical dosage was used to observe the physical changes (appearance, pH) of the compatibility liquid within 0-24 hours. The double wavelength spectrophotometry was adopted Separation Direct determination of Ranitidine Hydrochloride and tinidazole dextrose injection before and after compatibility changes. Results: At room temperature, the appearance and pH did not change obviously within 0-24 h. The content of tinidazole almost did not change. The content of ranitidine hydrochloride decreased within 24 h but not more than 10%. Conclusion: Ranitidine hydrochloride and tinidazole dextrose injection can be used in combination.