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目的掌握广州市户籍人口现阶段戊肝的流行状况,为制定预防控制措施以及将来戊肝疫苗免疫策略提供依据。方法采用分层、多阶段整群随机抽样方法,抽取广州市12个区/县级市1～59岁户籍人口共4989人,采集血清用酶联免疫法检测戊肝病毒IgG抗体(HEV IgG)。HEV IgG流行率采用调查权重进行加权估计并按广州市人口学结构进行调整,使用泰勒级数线形法估计率的方差,籍此构建率的95%置信区间并以此进行率的假设检验。结果广州市1～59岁人群HEV IgG流行率为10.77%(95%CI:9.33%～12.20%),人群中HEVIgG流行率随着年龄的增长而增高,差异有统计学意义,而与性别、居住地类型、文化程度、职业无关。结论广州市戊肝的流行情况不容低估,应进一步加强对戊肝的监测和调查力度。
Objective To understand the prevalence of hepatitis E at the current stage of census register in Guangzhou and provide evidence for the prevention and control measures and future immunization strategies for hepatitis E vaccine. Methods The stratified and multi-stage cluster random sampling method was used to collect 4989 population of 1-59-year-olds in 12 districts / counties in Guangzhou. Serum samples were collected for the detection of hepatitis E virus IgG antibody (HEV IgG) . The prevalence of HEV IgG was weighted by the survey weight and adjusted according to the demographic structure of Guangzhou. The variance of the rate was estimated using the Taylor series linear method. The 95% confidence interval of the rate of construction was used to test the hypothesis of rate. Results The prevalence of HEV IgG was 10.77% (95% CI: 9.33% ~ 12.20%) in Guangzhou population aged 1- 59 years. The prevalence of HEVIgG in population increased with age, the difference was statistically significant, but not with gender, Type of residence, educational level, occupation has nothing to do. Conclusion The prevalence of hepatitis E in Guangzhou should not be underestimated, and the monitoring and investigation of hepatitis E should be further strengthened.