作者在筛选由活化小鼠原T细胞产生的cDNA文库过程中,发现一种命名为淋巴细胞趋化因子的细胞因子,该因子类似于 Cys-Cys和 Cys-X-Cys趋化因子家族成员,但缺乏这些趋化因子特征性4个半胱氨酸残基中的两个Cys残基。除活化原T细胞产生该因子外,活化CD_8~+T细胞和CD_4~-CD_8~-T细胞受体αβ~+胸腺细胞也表达淋巴细胞趋化因子,此趋化因子对淋巴细胞有特异的趋化活性,但对单核 During the screening of cDNA libraries generated from activated mouse naive T cells, the authors found a cytokine named lymphocyte chemokine similar to Cys-Cys and Cys-X-Cys chemokine family members, But lacking two of the four cysteine ​​residues characteristic of these chemokines. In addition to the activation of pro-T cells to produce this factor, activated CD8 + T cells and CD4 ~ -CD8 ~ -T cell receptors αβ ~ + thymocytes also express lymphocyte chemokines, chemokines that are specific to lymphocytes Chemotactic activity, but mononuclear