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目的观察奥沙利铂(oxaliplatin,L-OHP)联合5-FU/CF治疗24例晚期大肠癌的疗效及不良反应。方法用L-OHP130mg/(m2.d1)联合5-FU500mg/(m2.d1~d4)/CF200mg/(m2.d1~d4)方案治疗24例转移性大肠癌,分别评价近期疗效及不良反应。结果24例受治者有效率为45.8%。主要不良反应为末梢神经炎和轻度骨髓抑制。Ⅲ度毒副反应主要为血小板的下降和腹泻。结论L-OHP联合5-FU/CF治疗晚期大肠癌安全有效。
Objective To observe the efficacy and adverse reactions of oxaliplatin (L-OHP) combined with 5-FU / CF in the treatment of 24 patients with advanced colorectal cancer. Methods Twenty-four patients with metastatic colorectal cancer were treated with L-OHP130mg / (m2.d1) combined with 5-FU 500mg / (m2.d1-d4) / CF200mg / (m2.d1-d4) regimen for short-term efficacy and adverse reactions. Results The effective rate of 24 cases was 45.8%. The main adverse reactions were peripheral neuritis and mild myelosuppression. Ⅲ degree of toxicity mainly for the decline of platelets and diarrhea. Conclusions L-OHP combined with 5-FU / CF is safe and effective in the treatment of advanced colorectal cancer.