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目的:观察福辛普利和卡维地洛联合治疗慢性充血性心力衰竭(CHF)的临床疗效。方法:60例CHF患者(NYHA心功能Ⅱ-Ⅳ级)在常规治疗的基础上随机分成2组,治疗组口服福辛普利和卡维地洛,对照组口服福辛普利,疗程4个月。结果:治疗组和对照组患者心功能及生活质量均得到改善,静息心率均降低,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)缩小,左室射血分数(LVEF)均得到提高,但治疗组较对照组明显,两组有显著性差异(P<0.05)。结论:福辛普利和卡维地洛联合治疗CHF可明显改善心功能,减慢心率,降低血压,缩小LVESD、LVEDD,提高LVEF。
Objective: To observe the clinical efficacy of fosinopril and carvedilol in the treatment of chronic congestive heart failure (CHF). Methods: Sixty CHF patients (NYHA cardiac function grade Ⅱ-Ⅳ) were randomly divided into two groups on the basis of conventional treatment. The patients in the treatment group were given oral fosinopril and carvedilol. The control group was given oral fosinopril. The course of treatment was 4 months . Results: The heart function and quality of life of patients in the treatment group and control group were improved, resting heart rate was decreased, left ventricular end-systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) Were improved, but the treatment group than the control group was significantly different between the two groups (P <0.05). Conclusion: The combination of fosinopril and carvedilol can significantly improve heart function, reduce heart rate, lower blood pressure, reduce LVESD and LVEDD and improve LVEF.