肾移植术后患者要长期服用免疫抑制剂预防或治疗移植物排斥反应,环孢素(CsA)是器官移植受者普遍应用的免疫抑制药之一。因其药动学个体差异大、治疗范围窄,需及时监测血药浓度,以保证其治疗效果,防止发生排异反应或毒性反应。临床监测过程中,发现CsA血药浓度水平易受性别、年龄、肥胖、肝肾功能、胃肠功能、药物相互作用以及饮 Long-term use of immunosuppressive agents in patients after renal transplantation to prevent or treat graft rejection, cyclosporine (CsA) is one of the commonly used immunosuppressive drugs in organ transplant recipients. Because of its large pharmacokinetic individual differences, narrow treatment, blood concentration monitoring in a timely manner to ensure its therapeutic effect, to prevent the occurrence of rejection or toxicity. During clinical monitoring, it was found that plasma CsA levels were susceptible to gender, age, obesity, liver and kidney function, gastrointestinal function, drug interactions, and drinking