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目的对氯吡格雷(波立维)联合阿司匹林对治疗急性心肌梗死的临床效果进行观察分析。方法随机选取2010年5月至2012年5月我院收治的急性心肌梗死患者88例,将其平均分为两组(对照组A组和观察组B组),每组44例,在常规治疗的基础上,A组仅给予肠溶阿司匹林每天100mg,观察组B组给予肠溶阿司匹林每天100 mg,氯吡格雷每天75 mg,每天一次,观察治疗期间(四周)心绞痛发生情况,心血管事件的发生情况,心脏功能的改善情况及药物的不良反应等。结果两组的总有效率比较发现观察组均要明显高于对照组(P<0.05),观察组在再发心梗、心衰、心律失常、心血管性死亡等心血管事件的发生方面明显好于对照组,副作用方面,两组患者均未出现严重出血,两组的胃肠道反应没有明显差异。结论氯吡格雷联合阿司匹林治疗急性心肌梗死临床治疗效果显著,而且可以降低心血管事件的发生率,副作用少,具有较好的安全性,值得临床借鉴推广。
Objective To observe and analyze the clinical effect of clopidogrel combined with aspirin in the treatment of acute myocardial infarction. Methods 88 cases of acute myocardial infarction admitted to our hospital from May 2010 to May 2012 were randomly divided into two groups (control group A and observation group B), 44 cases in each group. After routine treatment Group A received only 100 mg / day of enteric-coated aspirin, group B received 100 mg of enteric-coated aspirin daily, and clopidogrel 75 mg daily. The incidence of angina pectoris during the treatment period (four weeks), the incidence of cardiovascular events The situation, the improvement of cardiac function and adverse drug reactions. Results The total effective rate of the two groups was significantly higher than that of the control group (P <0.05). The observation group was more obvious in the recurrence of cardiovascular events such as recurrent myocardial infarction, heart failure, arrhythmia and cardiovascular death Better than the control group, side effects, no severe bleeding in both groups, the two groups did not differ significantly in gastrointestinal reactions. Conclusion Clopidogrel combined with aspirin in the treatment of acute myocardial infarction clinical significant effect, and can reduce the incidence of cardiovascular events, fewer side effects, with good safety, it is worth learning from the clinical reference.