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采用天花粉加前列腺素(PG)与中药抗早孕,共147侧,分三组进行。甲组:肌肉注射天花粉5毫克,40～48小时后阴道塞 PG 薄膜(内含15—甲基 PGF_(2α)酸2毫克),每2小时一次,最多用18张,再加中药。乙组:用药同甲组再加肌肉注射丙酸睾丸酮200毫克。丙组:天花粉加 PG 明胶海绵块(内含 PGF_(2α)酸4毫克),每8小时阴道塞药一次,最多用6块。中药方剂:三梭、莪术、泽兰、红花、川芎、益母草、香附、牛夕。结果:甲组49例,成功率93.9%;乙组51例,成功率98%;丙组47例成功率89.3%。147例中共有9例失败,总成功率为93.8%。引-流产时间平均4天12小时14分。随访率为87.9%,恶露平均13.1天净。对10例孕妇作血浆 hCG 及孕酮测定。用天花粉后48小时,血浆 hCG 已下降为注射前的23.7%,孕酮下降为原来的44%。72小时后血桨 hCG 下降到原来的13.3%,孕酮下降为原来的36.5%,血浆孕酮下降不如 hCG 快,二者下降幅度不呈正比,下降幅度与妊娠月份大小和流产快慢亦无明显关系。病理检查发现,绒毛滋养叶细胞变性坏死以外围的合体滋养叶细胞较明显。蜕膜病变亦随引产时间的延长而渐趋严重。电镜观察,除绒毛呈不同程度的变性坏死外,蜕膜亦明显变性坏死,蜕膜螺旋动脉有管腔缩小现象。
The use of TCS plus prostaglandin (PG) and Chinese medicine anti-early pregnancy, a total of 147 sides, divided into three groups. Group A: intramuscular injection of TCS 5 mg, 40 to 48 hours after vaginal plug PG film (containing 15-methyl PGF_ (2α) acid 2 mg), once every 2 hours, up to 18, plus traditional Chinese medicine. Group B: medication with a group plus intramuscular testosterone propionate 200 mg. Group C: TC combined with gelatin sponge block (containing PGF 2α acid 4 mg), vaginal plug medicine every 8 hours, with a maximum of 6. Herbal Prescription: three shuttle, Curcuma, Zeeland, safflower, Chuanxiong, Motherwort, Cyperus rotundus, Niu Xi. Results: A group of 49 cases, the success rate of 93.9%; B group 51 cases, the success rate of 98%; C group 47 cases success rate of 89.3%. A total of 147 cases failed in 9 cases, the total success rate of 93.8%.引 引 - Abortion time average 4 days 12 hours 14 minutes. Follow-up rate was 87.9%, lochia average 13.1 days net. 10 cases of pregnant women for plasma hCG and progesterone determination. 48 hours after the use of TC, plasma hCG has dropped to 23.7% before injection, progesterone decreased to 44% of the original. 72 h after the blood plasma hCG decreased to 13.3%, progesterone decreased to 36.5% of the original, plasma progesterone decline as fast as hCG, the decline was not proportional to the two, the extent of decline and the size of the month of pregnancy and abortion speed was no significant relationship. Pathological examination found that villous trophoblastic degeneration and necrosis peripheral syncytiotrophoblast cells more obvious. Decidua lesions also become increasingly serious with the extension of induction of labor. Electron microscopy, in addition to varying degrees of villus degeneration and necrosis, the decidua was also significantly degeneration and necrosis, decidual spiral arteries lumen narrowing phenomenon.