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目的了解我国新生儿疾病的疾病负担和1990-2010年的变化规律,为制定疾病预防控制措施提供依据。方法利用2010年全球疾病负担研究(GBD 2010)的结果,分性别和年龄组报告我国1990年和2010年新生儿疾病的患病数、死亡数、早死造成的生命损失年(YLL)、伤残造成的生命损失年(YLD)、伤残调整生命年(DALY)及它们的率,并计算各项指标20年间的增量和增幅。结果我国新生儿疾病<1岁组的患病情况、死亡情况和疾病负担指标均呈现下降趋势,与1990年相比,2010年的患病数、标化患病率、死亡数、标化死亡率、DALY、标化DALY率、YLL、标化YLL率、YLD和标化YLD率分别下降了42.18%、15.55%、75.76%、64.60%、75.70%、64.50%、75.76%、64.60%、48.21%和24.37%。2010年男性的患病情况、死亡情况和疾病负担指标均明显高于女性。与1990年相比,2010年早产并发症的死亡及疾病负担情况总体呈现下降趋势,各年龄组的患病率均呈现上升趋势,0~6天组仍是疾病死亡和疾病负担较重的年龄组。新生儿脑病各项指标均呈现下降趋势。新生儿败血症和其他感染性疾病0~6天组引起的患病率、YLD率呈上升趋势,增幅分别为14.04%和14.33%。结论按性别和年龄段分组的疾病负担能更准确地反映不同新生儿疾病造成的影响,可有针对性地提出防治措施。
Objective To understand the burden of disease and the changes of 1990 to 2010 in neonatal diseases in our country and provide evidence for the development of disease prevention and control measures. Methods Based on the results of the 2010 Global Burden of Disease Study (GBD 2010), the number of illnesses, the number of deaths, the year of life lost (YLL) caused by premature death, disability and disability in 1990 and 2010 in China were reported by gender and age group Resulting in the loss of life years (YLD), disability-adjusted life years (DALY) and their rates, and calculating the increment and increase of each indicator for 20 years. Results The prevalence, mortality and burden of disease in neonates with disease <1 year old in our country all showed a downward trend. Compared with 1990, the prevalence, standardized prevalence, number of deaths and standardization of death in 2010 Rates, DALY, standardized DALY rates, YLL, standardized YLL rates, YLD and standardized YLD rates decreased by 42.18%, 15.55%, 75.76%, 64.60%, 75.70%, 64.50%, 75.76%, 64.60%, 48.21 % And 24.37%. 2010 men’s illness, death and disease burden indicators were significantly higher than women. Compared with 1990, the mortality and burden of premature complications in 2010 showed an overall downward trend. The prevalence rates of all age groups showed an upward trend. In 0-6 day groups, the deaths and the burden of disease were still heavier group. Neonatal encephalopathy indicators showed a downward trend. Prevalence of neonatal sepsis and other infectious diseases in the 0-6 day group showed an upward trend in YLD rates of 14.04% and 14.33%, respectively. Conclusions The burden of disease grouped by sex and age group can more accurately reflect the impact of different neonatal diseases and preventive measures can be put forward in a targeted manner.