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目的:探讨正常妊娠和胎儿生长受限孕妇血清皮质醇浓度和ApoAI/ApoB的变化,以及这些改变与胎儿生长受限发病的关系。方法:采用放射免疫法及免疫透射比浊法,测定50例胎儿生长受限孕妇、294例正常妊娠孕妇、56例非妊娠妇女(对照组)的血清皮质醇浓度、载脂蛋白ApoAI、AgpoB和ApoAI/ApoB比值。结果:正常妊娠孕妇血清皮质醇浓度、ApoAI和ApoB含量随着孕周增长而升高,较对照组有显著差异性(P<0.01),ApoAI/ApoB比值随着孕周增长略有上升(P>0.05)。与正常妊娠组比较,胎儿生长受限组皮质醇浓度显著升高(P<0.01),ApoAI/ApoB明显下降(P<0.01)。结论:测定孕妇血清皮质醇浓度、ApoAI/ApoB比值可作为孕期早期诊断胎儿生长受限的指标。
Objective: To investigate the changes of serum cortisol level and ApoAI / ApoB in normal pregnancy and fetus with limited growth and the relationship between these changes and the incidence of fetal growth restriction. Methods: The levels of serum cortisol, apolipoprotein ApoAI, AgpoB and total cholesterol in 50 pregnant women with fetal growth restriction, 294 normal pregnant women and 56 non-pregnant women (control group) were measured by radioimmunoassay and immunoturbidimetry. ApoAI / ApoB ratio. Results: The levels of serum cortisol, ApoAI and ApoB in normal pregnant women increased with gestational age, significantly higher than those in control group (P <0.01). The ratio of ApoAI / ApoB increased slightly with gestational age (P > 0.05). Compared with the normal pregnancy group, the Cortisol concentration in fetal growth restriction group increased significantly (P <0.01) and ApoAI / ApoB decreased significantly (P <0.01). Conclusion: The determination of serum cortisol concentration in pregnant women, ApoAI / ApoB ratio can be used as an indicator of fetal growth during early pregnancy confined.