目的:对比肝动脉灌注化疗栓塞联合经皮微波凝固疗法与单纯肝动脉灌注化疗栓塞治疗中晚期肝癌的疗效差异。方法:将60例肝癌患者随机分为两组,治疗组(34例)予肝动脉灌注化疗栓塞联合经皮微波凝固疗法治疗,对照组(26例)单用肝动脉灌注化疗栓塞治疗,术后随访6～36个月,分析两组之间治疗效果、生存率与术后不良反应发生的差异。结果:治疗组PR 9例,SD 16例,PD 9例,对照组PR 4例,SD 13例,PD9例。治疗组生存12个月以上的有24例(70.59%),对照组仅6例(23.08%),治疗组与对照组1年生存率比较,P<0.01,显示差异有统计学意义。术后不良反应发生方面,两组比较差异无统计学意义。结论:肝动脉灌注化疗栓塞联合经皮微波凝固疗法治疗中晚期肝癌能提高疗效并且提高患者生存率。 OBJECTIVE: To compare the curative effects of transcatheter arterial chemoembolization combined with percutaneous microwave coagulation and hepatic arterial chemoembolization in the treatment of advanced hepatocellular carcinoma. Methods: Sixty patients with liver cancer were randomly divided into two groups. The treatment group (34 cases) was treated with transcatheter arterial chemoembolization combined with percutaneous microwave coagulation therapy. The control group (26 cases) was treated with transcatheter arterial chemoembolization alone The patients were followed up for 6 to 36 months. The differences between the two groups in the treatment effect, survival rate and postoperative adverse reactions were analyzed. Results: The treatment group PR 9 cases, SD 16 cases, PD 9 cases, control group PR 4 cases, SD 13 cases, PD 9 cases. There were 24 cases (70.59%) survived for more than 12 months in the treatment group and 6 cases (23.08%) in the control group. The 1-year survival rate of the treatment group was significantly lower than that of the control group (P <0.01). Adverse reactions occurred in the two groups, the difference was not statistically significant. Conclusion: Hepatic arterial infusion chemoembolization combined with percutaneous microwave coagulation therapy for advanced hepatocellular carcinoma can improve the curative effect and improve the survival rate of patients.