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结核杆菌蛋白 ESAT- 6具有独特的免疫刺激活性 ,能诱导长期免疫记忆 ,并能预防小鼠结核病。免疫 ESAT- 6与另一抗原的融合蛋白能增强对第二抗原的特异性 型免疫应答。许多细菌或病毒性疾病需要增强细胞介导免疫应答使之恢复或产生保护作用。作者构建了含ESAT- 6和 P71基因序列
Mycobacterium tuberculosis ESAT-6 has a unique immunostimulatory activity that can induce long-term immune memory and prevent tuberculosis in mice. A fusion protein that immunostimulates ESAT-6 with another antigen can enhance the specific immune response to the second antigen. Many bacterial or viral diseases require enhanced cell-mediated immune responses to be restored or have a protective effect. The authors constructed the ESAT-6 and P71 gene-containing sequences