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目的:分析恶性黑色素瘤的病理诊断,以进一步提高病理诊断水平。方法:将我院2010年1月-2015年1月期间收治的60例恶性黑色素瘤手术患者纳入本研究中,所有患者病理标本均通过相关抗体进行免疫标记。结果:本研究中的患者标本经过检测后可知,HMB-45阳性率为80%,s-100阳性率为95%,CK阳性率为15%,Ki67阳性率为80%,Vimentin阳性率为90%。同时患者经病理表现特征可将其分为上皮细胞型、梭形细胞型、混合型以及坏死型。结论:恶性黑色素瘤的病理表现复杂,对患者进行联合免疫抗体检测有助于临床诊断。
Objective: To analyze the pathological diagnosis of malignant melanoma to further improve the pathological diagnosis. Methods: Sixty patients with malignant melanoma who were treated in our hospital from January 2010 to January 2015 were enrolled in this study. All the patients’ pathological specimens were immunolabeled by related antibodies. Results: The specimens of patients in our study showed that the positive rate of HMB-45 was 80%, the positive rate of s-100 was 95%, the positive rate of CK was 15%, the positive rate of Ki67 was 80% and the positive rate of Vimentin was 90 %. At the same time, patients can be divided into epithelial cell type, spindle cell type, mixed type and necrotic type by pathological features. Conclusion: The pathological manifestation of malignant melanoma is complex, and it is helpful for the clinical diagnosis of patients with combined immune antibody detection.