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肌苷(Inosine)是一种次黄嘌呤核苷制剂,能透过细胞膜进入细胞内,可提高多种酶的活性,参与能量代谢和蛋白质合成。作者在应用肌苷治疗缺血性心脏病时,发现肌苷还具有抗心律失常作用。根据乌头碱(Aconitine)膜去极化作用,作者观察了乌头碱对豚鼠心脏室间隔细胞自发节律动作电位的影响,以及肌苷对这种异常影响的恢复作用。
Inosine is an inosine that penetrates the cell membrane into the cell and enhances the activity of many enzymes involved in energy metabolism and protein synthesis. When using inosine for ischemic heart disease, the authors found that inosine also has anti-arrhythmic effects. According to the depolarization of Aconitine membrane, the authors observed the effect of aconitine on the spontaneous rhythmic action potential of guinea pig ventricular septal cells and the effect of inosine on this abnormal effect.