答:苯巴比妥中毒时,为使苯巴比妥迅速从尿中排出体外以解毒,常采用碱化尿液的方法,其主要目的是使苯巴比妥在肾小管的再吸收减少。根据pH与转运的关系可知:酸性药物在碱性尿中排泄增加,碱性药物在酸性尿中排泄增加。苯巴比妥是一酸性药物,当中毒时,口服或静注碳酸氢钠,尿液的pH即可升高。在此碱性环境中,苯巴比妥的解离度增大,非离 A: Phenobarbital poisoning, in order to make phenobarbital quickly excreted from the urine in order to detoxify, often using alkalinized urine method, its main purpose is to make phenobarbital tubular reabsorption reduced. According to the relationship between pH and transport shows: acidic drugs in alkaline urine excretion increased, alkaline drugs in acidic urine excretion increased. Phenobarbital is an acidic drug, when poisoned, orally or intravenously with sodium bicarbonate, urine pH can be increased. In this alkaline environment, phenobarbital dissociation increases, non-isolated