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目的 为预防膀胱癌术后复发。方法 对４０例膀胱癌患者于术中或ＴＵＲＢＴ术后癌肿切缘周围组织粘膜下注射５０万ｕ ＩＬ－ ２，以后每３ 月定期用自制输尿管导管针注射。并联合应用ＢＣＧ１２０ ｍ ｇ＋ ＩＬ－ ２１０ｕ 膀胱内灌注。同时随机对３０例同期膀胱癌术后患者用丝裂霉素Ｃ４０ｍｇ 膀胱内灌注为对照组。结果 随访４－ ７２个月，平均２８．６ 个月。无肿癌复发率ＩＬ－ ２膀胱内注射及ＩＬ－２＋ ＢＣＧ灌注组９５％ ，丝裂霉素Ｃ灌注组（对照组）８６．７％ 。比较两组有显著性差异（Ｐ＜ ０．０５）。结论 ＩＬ－ ２ 膀胱内注射及ＢＣＧ＋ ＩＬ－ ２ 联合膀胱内灌注防止膀胱癌术后复发更为有效。内注射ＩＬ－ ２，并于术后２ 周开始用ＢＣＧ＋ ＩＬ－ ２ 联合膀胱内灌注，这样可使血和尿ＩＬ－ ２ 水平长时间增高，且可有效观察肿瘤是否复发，可以充分发挥ＩＬ－ ２淋巴因子对肿瘤细胞的杀伤作用，ＢＣＧ还可使膀胱粘膜移行细胞变薄，刺激Ｔ细胞增殖转化成特异性细胞毒性Ｔ细胞，使局部呈炎性反应。我们行膀胱镜检时发现ＩＬ２ 膀胱内注射及ＢＣＧ＋ ＩＬ２ 膀胱灌注３ 月左右，病人的膀胱粘膜失去正常结构，膀胱粘膜变白，表面有炎性渗出物，呈“板块状”，弹性差，组织脆弱，这
The purpose is to prevent postoperative recurrence of bladder cancer. Methods Forty cases of bladder cancer were injected subcutaneously with 500 000 u IL-2 into the peri-urethra tissues around the incision on the edge of the cancer after TURBT. Then every March, they were injected with homemade ureteral catheter. BCG 120 m g + IL-210u intravesical instillation was used in combination. At the same time, 30 patients with bladder cancer at the same period were treated with intravesical instillation of mitomycin C40mg as the control group. The results were followed up for 4-72 months, an average of 28.6 months. No tumor recurrence rate IL-2 intravesical injections and IL-2 + BCG perfusion group 95%, mitomycin C infusion group (control group) 86.7%. There was significant difference between the two groups (P <0.05). Conclusion Intravesical instillation of IL-2 and combined intravesical instillation of BCG + IL-2 prevent the recurrence of bladder cancer more effectively. Intraperitoneal injection of IL-2, and 2 weeks after the start with BCG + IL-2 intravesical instillation, so that blood and urine IL-2 levels increased for a long time, and can effectively observe the tumor recurrence, can fully play IL- 2 lymphocyte cytotoxicity of tumor cells, BCG can also make the bladder mucosa transitional cell thinning, stimulate T cell proliferation into specific cytotoxic T cells, the local inflammatory reaction. Cystoscopy we found IL 2 intravesical injections and BCG + IL 2 bladder perfusion around March, the patient’s bladder mucosa loses its normal structure, the bladder mucosa turns white, the surface of inflammatory exudate was “plate-like” Poor elasticity and weak tissue