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目的:观察MDM2在恶性纤维组织细胞瘤组织中的表达,探讨MDM2的表达与恶性纤维组织细胞瘤预后的关系。方法:采用原位杂交方法检测66例恶性纤维组织细胞瘤组织中MDM2的表达,分析其表达与恶性纤维组织细胞瘤的临床分期、生存期的关系。结果:MDM2在生存期≥5年的表达率明显低于生存期<5年的表达率,在Ⅰ~Ⅱ期的表达率明显低于在Ⅲ~Ⅳ期的表达率,二者有显著性差异(P<0.05)。结论:MDM2与恶性纤维组织细胞瘤患者的预后成负相关。
Objective: To observe the expression of MDM2 in malignant fibrous histiocytoma and to explore the relationship between the expression of MDM2 and the prognosis of malignant fibrous histiocytoma. Methods: The expression of MDM2 in 66 cases of malignant fibrous histiocytoma was detected by in situ hybridization. The relationship between the expression of MDM2 and the clinical stage and survival of malignant fibrous histiocytoma was analyzed. Results: The expression rate of MDM2 in survival ≥ 5 years was significantly lower than that in survival <5 years, the expression rate in stage Ⅰ ~ Ⅱ was significantly lower than that in stage Ⅲ ~ Ⅳ, the difference was significant (P <0.05). Conclusion: MDM2 is negatively correlated with the prognosis of patients with malignant fibrous histiocytoma.