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目的:探讨早孕妇女应用异丙酚行无痛人工流产术前阴道放置卡前列甲酯栓对宫颈的软化和扩张作用。方法:选择自愿终止妊娠的早孕妇女4 000例随机分为4组,于人工流产术前不同时间阴道放置不同剂量的卡前列甲酯栓。结果:术前阴道放置卡前列甲酯栓的患者比没有放的手术时间亦明显缩短(P<0.01),麻醉药物用量减少(P<0.01),术中反应小(P<0.01)。术前1~2 h阴道后穹窿放置卡前列甲酯栓1 mg组阴道出血率与不全流产率较术前3~4 h放药组及药量2 mg组均明显减少(P<0.01)。结论:术前1~2 h阴道应用卡前列甲酯栓1 mg,可达到良好的宫颈软化和扩张结果,有效提高手术质量,减少并发症。
OBJECTIVE: To investigate the effect of propofol on vaginal softening and dilatation of vagina before painless artificial abortion in early pregnant women. Methods: 4 000 pregnant women who chose to terminate pregnancy voluntarily were randomly divided into 4 groups. Different doses of carbamazepine were placed vaginally at different time before induced abortion. Results: The preoperative vaginal thiazolyl ester suppository was significantly shorter (P <0.01), the dosage of narcotic drugs was decreased (P <0.01), and the intraoperative response was smaller (P <0.01). The rate of vaginal bleeding and incomplete abortion in 1 mg of cardinal methylester suppository 1 ~ 2 h before vaginal fornixation were significantly lower than those of 3 ~ 4 h before drug release and 2 mg dose (P <0.01). CONCLUSION: 1 mg of cardinal methylester suppository can be obtained vaginally 1 ~ 2 h before operation, and good cervical softening and dilatation results can be achieved, which can effectively improve the quality of operation and reduce the complications.