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目的 通过体内外抗病毒实验研究贯叶金丝桃抗流感病毒作用。方法 接种甲 1型流感病毒鼠肺适应株于狗肾细胞 (MDCK ) ,观察贯叶金丝桃醇提物体外抗流感病毒作用 ;体内实验以病毒滴鼻感染小鼠 ,观察肺指数、病毒致小鼠病死率等。结果 贯叶金丝桃 50g/L浓度组有明显抑制病毒致细胞病变的作用 ;贯叶金丝桃醇提物 10 0mg/kg和 10mg/kg对流感病毒引起的小鼠肺炎实变有明显的抑制作用 ,10 0mg/kg浓度组能延长流感病毒感染小鼠的生存时间。结论 贯叶金丝桃醇提物可抑制流感病毒的增殖 ,是一种治疗流行性感冒的有效药物
Objective To study the anti-influenza virus effect of Hypericum perforatum through in vitro and in vivo antiviral experiments. METHODS: Inoculation of mouse influenza type 1 strain of influenza virus type 1 in dog kidney cells (MDCK) was used to observe the anti-influenza virus effect of Hypericum pertussis extract; in vivo experiments were performed with viral intranasal infection of mice to observe lung index and virus-induced mice. Mortality and so on. Results The concentration of Hypericum perforatum at 50g/L significantly inhibited the cytopathogenic effect of virus; the Hypericum perforatum extracts 100mg/kg and 10mg/kg had a significant inhibitory effect on influenza virus-induced pneumonia in mice. 10 The 0 mg/kg concentration group prolongs the survival of influenza virus-infected mice. Conclusion Hypericum perforatum can inhibit the proliferation of influenza virus and it is an effective drug for the treatment of influenza.