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目的系统评价精氨酸强化的肠外营养(arginine-parenteral nutrition,Arg-PN)对结直肠癌患者免疫功能的影响。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库、重庆维普数据库、会议和博士论文数据库、Medline和Embase数据库中关于Arg-PN对结直肠癌患者免疫功能影响的随机对照试验文献,评价纳入文献质量后应用RevMan 5.0.软件进行Meta分析。结果总计纳入文献8篇,均为针对Arg-PN的病例对照研究;Meta分析结果显示,经治疗一周后Arg-PN对细胞免疫水平的影响:试验组中CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异均具有统计学意义(P<0.05);对体液免疫水平的影响:试验组中IgM、IgG水平均高于对照组,差异亦具有统计学意义(P<0.05)。结论 Arg-PN的强化肠外营养治疗对于结直肠癌患者免疫水平有正向调节作用,在未来的结直肠癌临床治疗实践中具有前瞻性的指导意义。
Objective To evaluate the effect of arginine-parenteral nutrition (Arg-PN) on immune function in patients with colorectal cancer. Methods A computer-based online search of CNKI, Wanfang database, Chongqing VIP database, conference and doctoral dissertation database, Medline and Embase database for randomized controlled trials on the effect of Arg-PN on immune function in patients with colorectal cancer was included. After the quality of the literature, RevMan 5.0 software was used for meta-analysis. The results were included in the literature of 8 articles, all for the case-control study of Arg-PN; Meta analysis showed that after a week of treatment of Arg-PN on cellular immunity levels: experimental group CD4 +, CD4 + / CD8 + levels higher than the control group (P <0.05). The level of IgM and IgG in the experimental group were higher than that in the control group (P <0.05), and the differences were also statistically significant (P <0.05) ). Conclusions The intensive parenteral nutrition therapy with Arg-PN has a positive regulatory effect on the immune status of patients with colorectal cancer and has prospective guiding significance in the future clinical practice of colorectal cancer.