OBJECTIVE:To evaluate the clinical efficacy of nourishing Yin and tonifying Yang sequential therapy (NYTYST) in combination with the West Medicine Climen in treating diminished ovarian reserve (DOR).METHODS:From September 2014 to September 2016,46 patients with DOR who received NYTYST and Climen (treatment group) and 51 patients who received Climen only (control group) at the Jiangsu Provincial Traditional Chinese Medicine Hospital (Nanjing,China) were retrospectively reviewed.Before and at 3 months after treatment,serum levels of follicle-stimulating hormone (FSH),FSH/luteinizing hormone (LH),estradiol (E2),and anti-Mullerian hormone (AMH),the antral follicle count (AFC),stromal peak systolic velocity (PSV),symptom scores,and the clinical effectiveness rate were measured and compared between the two groups.RESULTS:After treatment,serum levels of FSH,FSH/LH and E2,and symptom scores were significantly decreased compared with before treatment (all P ＜ 0.05) in the two groups.AMH levels,AFC,and PSV were significantly increased after treatment compared with before treatment in both groups (all P ＜ 0.05).Serum levels of FSH,FSH/LH,and E2 after treatment were significantly lower in the treatment group than in the control group (all P ＜ 0.05).However,AMH levels and the AFC were significantly higher after treatment in the treatment group than in the control group (both P ＜0.0S).The clinical effectiveness rate was significantly higher in the treatment group than in the control group (87％ vs 68.6％,P ＜ 0.05).CONCLUSION:NYTYST combined with Climen may be more effective in treating DOR than Climen alone.