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目的 :观察吗丁啉治疗新生儿胃食道返流疗效。方法与结果 :对 6 2例胃食道返流患者随机分为治疗组和对照组。对照组仅采用传统的体位疗法 ,治疗组在此基础上加用口服吗丁啉止吐进行观察疗效。治疗 1天止吐为显效 ,治疗 2天止吐为有效 ,治疗 2天以上仍有呕吐为无效。结论 :吗丁啉止吐总有效率明显高于对照组 ,P <0 .0 1,且未发现副作用。因此 ,吗丁啉可作为新生儿胃食道返流的首选药。
Objective: To observe the efficacy of domperidone in the treatment of neonatal gastroesophageal reflux disease. Methods and Results: Sixty-two patients with gastroesophageal reflux were randomly divided into treatment group and control group. The control group only used traditional postural therapy. The treatment group was treated with oral domperidone and antiemetic to observe the curative effect. One day treatment for antiemetic markedly effective treatment for 2 days antiemetic effective, more than 2 days treatment is still vomiting is invalid. Conclusion: The total effective rate of domperidone antiemetic was significantly higher than that of the control group, P <0.01, and no side effects were found. Therefore, domperidone can be used as neonatal gastroesophageal reflux drug of choice.