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目的探索可复制重度颅脑损伤实验大鼠动物模型的制作。方法采用改良自由落体装置,撞击80例麻醉后实验鼠颅骨穹窿部,砝码质量50~200 g,高度20~50 cm,撞击后观察时间为4 h~12 d,麻醉后取脑,制作652张病理切片,观察脑病理切片与临床脑创伤的相关性。结果确认最佳冲击力为10 000 g/cm,病理改变与临床有显著相关性,对重型创伤性颅脑损伤的诊治有参考价值。运用模拟临床的闭合性减压术与开放性减压术对比,获得有益提示,后者更有利于脑创伤康复。结论通过本实验找到创伤性重型颅脑损伤大鼠最佳致伤冲击力,实验动物与临床有显著相关性,开放减压比闭合减压更有利于脑康复。
Objective To explore the animal model of rat with reproducible severe craniocerebral injury. Methods A modified free-fall device was used to impact the cranial vault of 80 rats after anesthesia. The weights were 50-200 g and the height was 20-50 cm. After the impact, the observation time was 4 h-12 d. After anesthesia, the brain was taken and made 652 Zhang pathological sections to observe the correlation between brain pathology and clinical brain trauma. The results confirmed that the best impact of 10 000 g / cm, pathological changes and clinical significant correlation, diagnosis and treatment of severe traumatic brain injury have reference value. Using simulated clinical closed decompression and open decompression contrast, access to useful tips, the latter is more conducive to brain trauma rehabilitation. Conclusions This study found that the best traumatic impact of traumatic brain injury in rats, experimental animals and clinical significant correlation, open decompression than closed decompression more conducive to brain rehabilitation.