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目的探讨人类白细胞抗原(Human Leukocyte Antigens,HLA)DP基因多态性与中国汉族人群肺癌遗传易感性的关联。方法应用Taq Man探针方法检测401例肺癌患者和843例对照者rs3077和rs9277535位点基因型,比较不同基因型与肺癌患病风险的关系。结果采用多因素Logistic回归分析,结果显示rs3077和rs9277535位点突变基因型AA显著增加肺癌的发病风险(调整OR=1.69,95%CI=1.16~2.51;调整OR=1.58,95%CI=1.10~2.25);单倍型分析显示,与GG单倍型相比,携带AA单倍型的个体可增加肺癌发病风险(调整OR=1.41,95%CI=1.61~1.71);与携带rs3077GG+GA and rs9377357 GG基因型的个体相比,携带1~4个危险等位基因的个体发生肺癌的风险显著(P趋势<0.01)。结论 HLA基因多态性与中国汉族人群肺癌的发病风险存在关联。
Objective To investigate the association of human Leukocyte Antigens (HLA) DP gene polymorphism with susceptibility to lung cancer in Chinese Han population. Methods The genotypes of rs3077 and rs9277535 in 401 lung cancer patients and 843 controls were detected by TaqMan probe and the relationship between different genotypes and the risk of lung cancer was compared. Results The multivariate Logistic regression analysis showed that the genotypes AA at rs3077 and rs9277535 significantly increased the risk of lung cancer (adjusted OR = 1.69, 95% CI = 1.16-2.51; adjusted OR = 1.58, 95% CI = 2.25). Haplotype analysis showed that compared with GG haplotype, individuals carrying AA haplotype could increase the risk of lung cancer (adjusted OR = 1.41, 95% CI = 1.61-1.71) There was a significant risk of lung cancer in individuals carrying one to four risk alleles (P trend <0.01) compared to rs9377357 GG genotype individuals. Conclusion HLA gene polymorphism is associated with the risk of lung cancer in Chinese Han population.