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目的：调查河北省蔚县居民高尿酸血症与痛风的流行情况，并观察高尿酸血症与体重指数、收缩压、血浆胆固醇、甘油三脂和空腹血糖的相关性。方法采用随机、分层、整群抽样的方法,调查了该县各地区7,083名20岁以上居民的高尿酸血症和痛风的患病情况。结果①血尿酸水平及高尿酸血症情况：总体血尿酸水平为（345.43±68.52）μmol/L，其中男性为（371.82±78.22）μmmol/L，女性为（315.28±73.67）μmmol/L；高尿酸血症患病率为15.40%，男性患病率为16.88%，女性为10.83%；②痛风患病率：痛风125例，痛风患病率为1.76%，其中男113例（2.11%），女12例（0.70%）；③与血尿酸正常组比较，高尿酸血症组体重指数、收缩压、血浆甘油三酯、胆固醇和空腹血糖水平均明显升高，差异有统计学意义。结论河北省蔚县人群高尿酸血症及痛风患病率均呈现升高趋势。高尿酸血症患者易合并高血压、高脂血症、糖尿病等疾病，表明作为心血管疾病的危险因素，高尿酸血症患病率仍在继续升高，高尿酸血症已经成为危胁人类健康的重要隐患。“,”Objective To investigate the prevalence of hyperuricemia and gout in community of Yu County in Hebei Province, and explore the relevance between hyperuricemia and body mass index (BMI), systolic pressure, plasma cholesterol, triglyceride and fasting blood-glucose.Methods A random stratified cluster sampling was conducted, and 7,083 inhabitants aged over 20 years were investigated for prevalence of hyperuricemia and gout. Results①Blood uric acid level and hyperuricemia situation: The mean blood uric acid level was (345.43±68.52)μmol/L, (371.82±78.22)μmmol/L in the male and (315.28±73.67)μmmol/L in the female. The total incidence of hyperuricemia was 15.40%, 16.88% in men and 10.83% in women.②Incidence situation of gout: The number of patients suffering from gout was 125, gout prevalence rate was 1.76%, including 113 men (2.11%), 12 women (0.70%).③Compared with normal uric acid group, the body mass index and systolic pressure were higher, the blood level of plasma cholesterol, triglyceride and fasting blood-glucose were higher in hyperuricemia group. Conclusion The prevalence of hyperuricemia and gout in community of Yu County in Hebei Province was higher than other districts in China. The rate of over-weighted, hyperlipidemia, hypertension and diabetes was higher in hyperuricemia group. All these suggested hyperuricemia, as a risk factor for cardiovascular disease, hyperuricemia prevalence rate is still continuing to rise, and hyperuricemia has become a major hazard to human health risks.