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藁本内酯是川芎和当归的主要有效成分,其化学结构的不稳定性限制了它的进一步研究和临床应用。本实验通过色谱方法对其室温静置一个月后的产物进行制备,得到了14个藁本内酯的转化产物,并通过ESIMS、NMR等光谱分析法确定了其结构,包括一个新化合物7’-carboxyl-wallichilide(1)。利用LC-MS峰面积归一化法,确定了藁本内酯及其转化产物的相对含量,阐明了藁本内酯的主要转化产物为其二聚体。
The ligustilide is the main active ingredient of Rhizoma Chuanxiong and Angelica sinensis, and the instability of its chemical structure limits its further research and clinical application. In this experiment, the products of which after one month of standing at room temperature were prepared by chromatography, and the products of 14 ligustilide were obtained. Their structures were confirmed by ESIMS, NMR and other spectroscopic methods, including a new compound 7 ’ -carboxyl-wallichilide (1). Using LC-MS peak area normalization method, the relative content of ligustilide and its conversion products was determined, and the main conversion product of ligustilide was identified as its dimer.