【摘 要】
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Background rnOrganofluorine compounds play an important role in pharmaceuticals,agrochemicals and material sciences owing to the unique nature of fluorine.[1] R
【机 构】
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State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai Unive
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Background rnOrganofluorine compounds play an important role in pharmaceuticals,agrochemicals and material sciences owing to the unique nature of fluorine.[1] Recently,OCF3 group has received increasing attention owing to its good metabolic stability and high lipophilic properties.For example,the OCF3 group has one of the highest lipophilicity value (πx =1.04) compared to that of the CF3 (πx =0.88) and SO2CF3 (πx =0.55),[2] which might improve metabolic profiles when it is introduced into the appropriate position of parent molecules.Consequently,the development of new methods for the synthesis of trifluoromethoxylated compounds has attracted considerable interest in synthetic organic chemistry during the last five years.[3] However,compared to the asymmetric fluorination,mono-,di-,trifluoromethylation,and trifluoromethylthiolation,[4] the asymmetric trifluoromethoxylation is still in the embryonic stage.At present,there are only five examples for the enantioselective construction of trifluoromethoxylated stereogenic carbon centers,and this article would focus on the development of this field.
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