天然产物由于具有结构多样性和新颖性,具有独特的生理活性和新的作用机制,因此是开展化学生物学研究的重要工具,同时也是创新药物和先导化合物的重要来源.最近,我们研究发现天然活性化合物腺花素能够在体内和体外诱导维甲酸敏感和耐药的急性粒细胞性白血病细胞发生分化,有效延长白血病小鼠生存时间.在此基础上,以腺花素为分子探针,“垂钓”其潜在的靶分子,结果发现腺花素特异性靶向过氧化还原酶(Peroxiredoxin)Ⅰ//Ⅱ蛋白,导致H2O2的积聚,H2O2作为第二信使可诱导白血病细胞分化的信号通路.本文对这些工作做了论述和展望. Natural products, as a result of their structural diversity and novelty, their unique physiological activities and new mechanisms of action, are important tools for conducting chemical biology research as well as an important source of innovative drugs and lead compounds.Recently, we found that natural The active compound, adenocarcinoma, can induce differentiation and differentiation of acute myeloid leukemia cells that are sensitive and resistant to retinoic acid in vivo and in vitro, and effectively prolong the survival time of leukemia mice. On the basis of this, adenocarcinoma as a molecular probe, “Fishing” its potential target molecules, and found that adenosine specifically target peroxiredoxin Ⅰ / Ⅱ protein, resulting in the accumulation of H2O2, H2O2 as a second messenger can induce leukemia cell differentiation signal pathway This article discusses and looks at these tasks.