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[目的]探讨不同组方中药对慢性萎缩性胃炎伴不典型增生大鼠胃黏膜形态、组织学改变的影响。[方法]采用化学药物刺激的方法复制慢性萎缩性胃炎癌前病变动物模型并分组用药物干预。用酶标仪检测各组大鼠胃组织中Caspase-3表达的变化。[结果]无论是预防组还是治疗组,中药、西药的干预均可以使Caspase-3的表达增加,与模型大鼠比较差异有统计学意义(P<0.05);健脾化瘀方要优于其他药物。[结论]各组中药均可以通过增加胃组织中Caspase-3的表达达到对胃癌前病变的治疗作用,其中健脾化瘀方治疗萎缩性胃炎癌前病变的作用要明显优于健脾益气方、活血化瘀方。
[Objective] To investigate the effects of different prescriptions on the morphology and histological changes of gastric mucosa in rats with chronic atrophic gastritis accompanied by atypical hyperplasia. [Methods] The animal models of precancerous lesions of chronic atrophic gastritis were replicated by means of chemical stimulation and divided into groups with drug intervention. The changes of Caspase-3 expression in gastric tissue of each group were detected by microplate reader. [Result] The intervention of traditional Chinese medicine and western medicine could increase the expression of Caspase-3, both in the prevention and treatment groups (P <0.05). The prescription of Jianpi Huayu prescription was better than that of the model group Other drugs. [Conclusion] All groups of traditional Chinese medicine can achieve the therapeutic effect on gastric precancerous lesions by increasing the expression of Caspase-3 in gastric tissue. The effect of Jianpi Huayu Recipe in treating precancerous lesions of atrophic gastritis is obviously better than that of Jianpi Yiqi Square, blood circulation side.