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本文指出口服BCG疫苗对移植鼠肉瘤的腹腔肿瘤及肺转移瘤无效,并且不能控制移植上皮瘤的术后肺转移。每天口服BCG 0.5毫克不能抑制M_o57肉瘤的发展。但是,单次注射BCG 100毫克到腹腔内,可完全抑制肿瘤生长。单次注射BCG疫苗到肺组织可使肺肉瘤细胞完全吸收。反复静脉注射BCG可使切除后的上皮瘤肺转移明显减少。但不能排除口服BCG有全身免疫刺激作用,并可能有一些临床疗效。不过明显的肿瘤抑制乃是肿瘤细胞与BCG接触
This article points out that oral BCG vaccine has no effect on abdominal cavity tumors and pulmonary metastases of transplanted mouse sarcoma, and can not control postoperative lung metastasis of transplanted epithelial tumors. Daily oral administration of 0.5 mg BCG did not inhibit the development of M_o57 sarcoma. However, a single injection of 100 mg of BCG into the abdominal cavity completely inhibited tumor growth. A single injection of the BCG vaccine to lung tissue can completely recruit the lung sarcoma cells. Intravenous injection of BCG can significantly reduce lung metastasis after resection of epithelial tumors. However, it cannot be ruled out that oral BCG has systemic immunostimulatory effects and may have some clinical efficacy. However, the obvious tumor suppression is the contact between tumor cells and BCG.