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目的:探讨四物汤灌胃给药对大鼠脑缺血再灌注损伤的神经保护作用。方法:构建大鼠脑缺血再灌注模型,随机分组,于大鼠脑缺血前经灌胃给予100 mg/kg、200 mg/kg、400 mg/kg四物汤,在脑缺血后24 h进行大鼠脑TTC染色、神经学功能评分、脑水含量的测定。结果:四物汤治疗能显著地缩小脑梗死体积,减轻神经功能的损伤并减轻了脑水肿。结论:四物汤能够减少缺血性脑中风的损伤。
Objective: To investigate the neuroprotective effect of Siwu Tang by intragastric administration on cerebral ischemia-reperfusion injury in rats. Methods: The model of focal cerebral ischemia-reperfusion in rats was established. The rats were randomly divided into four groups: 100 mg / kg, 200 mg / kg and 400 mg / kg Siwu Tang before intracerebral ischemia, h rat brain TTC staining, neurological function score, determination of brain water content. Results: Siwu Tang treatment can significantly reduce the volume of cerebral infarction, reduce neurological damage and reduce cerebral edema. Conclusion: Siwu Decoction can reduce the damage of ischemic stroke.