柯兴综合征选行双侧肾上腺切除术后每易出现Nelson综合征。本文分析50例术后随诊2～23年(平均13年)的结果。其中15例(30%)术后1%～12年(平均4.6年)内出现Nelson综合征。内10例作了经蝶窦垂体瘤摘除手术,女9例,男1例。年龄22～61岁(平均36.6岁)。10例均有显著皮肤色素沉着;9例蝶鞍有X线改变;2例视力障碍;6例头痛;1例(22 Cushing syndrome is selected after bilateral adrenalectomy for Nelson syndrome. This article analyzes the results of 50 cases of follow-up after 2 to 23 years (average 13 years). Nelson syndrome occurred in 15 (30%) patients within 1% to 12 years (mean 4.6 years) after surgery. Internal sphenoid sinus pituitary tumors were performed in 10 patients, including 9 females and 1 male. Age 22 to 61 years old (average 36.6 years old). All 10 cases had significant skin pigmentation; 9 cases had sphenoid saddle X-ray changes; 2 cases had visual impairment; 6 cases had headache; 1 case (22 cases)