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目的醒脑静注射液序贯清开灵颗粒对老年急性缺血性脑血管病的干预作用,并探讨其作用机制。方法采用随机数字表法,观察病人60例,其中常规治疗+醒脑静注射液序贯清开灵颗粒组20例,常规治疗+醒脑静注射液20例,对照组(常规组)20例,通过观察各组的神经功能缺损评分,同时均通过化学发光法检测各组患者治疗后的IL-6和TNF-α的含量。结果加用醒脑静组及醒脑静序贯清开灵颗粒组治疗患者的神经功能缺损评分均较对照组显著降低,且加用醒脑静组及醒脑静序贯清开灵颗粒组治疗患者的血清中的IL-6及TNF-α的含量较对照组显著降低(P<0.01),且加用醒脑静注射液组与醒脑静注射液序贯清开灵颗粒组治疗患者的神经功能缺损评分及血清中的IL-6及TNF-α的含量比较无明显差异(P>0.05)。结论醒脑静注射液序贯清开灵颗粒治疗老年急性缺血性脑血管病通过降低血清中的IL-6、TNF-α的含量,产生保护血管内皮的作用。
Objective: To observe the intervention effect of Xingnaojing injection on Qinglie granule in senile patients with acute ischemic cerebrovascular disease and its mechanism. Methods Sixty patients were observed by random number table method. Among them, 20 cases were treated routinely with Qingkailing Injection and 20 cases were treated with Qingkailing Granule, 20 cases were treated with routine treatment and Xingnaojing Injection, 20 cases in control group (conventional group) The neurological deficit score of each group was observed. At the same time, the levels of IL-6 and TNF-α in each group were detected by chemiluminescence. Results Compared with the control group, the scores of neurological deficit plus Xingnaojing group and Xingkaijing group were significantly lower than those of the control group The levels of IL-6 and TNF-α in serum of the treated patients were significantly lower than those in the control group (P <0.01), and the combined treatment of Xingnaojing injection and Xingnaojing injection in the sequential Qingkailing granules group Neurological deficit scores and serum IL-6 and TNF-α content was no significant difference (P> 0.05). Conclusion Xingnaojing injection sequential Qingkailing granules treatment of senile acute ischemic cerebrovascular disease by reducing serum levels of IL-6, TNF-α, resulting in the protection of vascular endothelial role.