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[目的]观察布拉氏酵母菌联合复方谷氨酰胺对腹泻型肠易激综合征的临床疗效.[方法]随机将入选的104例腹泻型肠易激综合征患者分为治疗组和对照组,治疗组患者给予布拉氏酵母菌联合复方谷氨酰胺治疗,对照组患者仅给予复方谷氨酰胺治疗,比较2组患者临床疗效、血清血管活性肠肽(VIP)和生长抑素(SS)水平及不良反应发生情况.[结果]治疗组临床疗效总有效率为94.23％,较对照组的76.92％显著提高,尤其是治疗组患者治愈率高达30.77％,而对照组的治愈率仅为17.31％,治疗后治疗组的VIP、SS水平均显著低于对照组(P＜0.01),治疗组止泻时间、腹泻次数、急性应激次数较对照组显著缩短和减少,差异均具有统计学意义(P＜0.05).[结论]布拉氏酵母菌联合复方谷氨酰胺治疗腹泻型肠易激综合征可显著提高临床疗效,减少患者腹泻次数,缩短其止泻时间,降低VIP和SS水平,改善腹痛腹胀等临床症状,值得进一步在临床上推广.“,”[Objective]To evaluate the clinical efficacy of Brucella combined with compound glutamine in the treatment of diarrhea-predominant irritable bowel syndrome. [Methods]We recruited 104 patients with diarrhea-predominant irritable bowel syndrome and divided them into treatment group and control group randomly. Patients in the treatment group were treated with Brassica napus combined with compound glutamine and patients in control group were treated with compound glutamine. The clinical efficacy, anti-diarrheal effect, VIP and SS levels before and after treatment and adverse reactions between the two groups were compared. [Results]The total effective rate and cure rate in the treatment group were 94.23％ and 30.77％ respectively, which were significantly higher than those in the control group(P＜0.05). The levels of VIP and SS in the treatment group were significantly lower than those in the control group, and the difference was statistically significant(P＜0.05). The time for diarrhea relief, diarrhea frequency, frequency of acute stress in treatment group were all significantly lower than control group(P＜0.05). [Conclusion] Saccharomyces boulardii combined with compound glutamine in the treatment of diarrhea-predominant irritable bowel syndrome can significantly improve the clinical curative effect, reduce the diarrhea frequency, shorten the diarrhea duration, decrease the level of VIP and SS, relieve abdominal pain and other clinical symptoms, which is worthy of further clinical promotion.