顺铂是一种抗瘤谱广 ,对多种肿瘤疗效均较满意的一种药物 ,但其肾毒性一直限制着临床的广泛应用。我科自2 0 0 1年 6月— 2 0 0 2年 1月用细胞保护剂阿米福汀结合大剂量顺铂治疗 12例患者效果较好 ,现报告如下。1　材料与方法采用随机分组方法 :全部化疗方案均含有 PDD10 0 m g Cisplatin is a broad anti-tumor spectrum, a variety of tumors are more satisfied with the efficacy of a drug, but its nephrotoxicity has been limited to a wide range of clinical applications. Our department from June 2001 - January 2002 with the cytoprotectant paclitaxel combined with high-dose cisplatin in 12 patients with better results are as follows. 1 Materials and Methods Randomized grouping: All chemotherapy regimens contained PDD10 0 m g