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目的:观察普拉克索治疗早期帕金森病的疗效。方法:早期帕金森病患者70例随机分为普拉克索组35例,金刚烷胺组35例,治疗12周。治疗前后进行改良的威伯斯特(Webster)评分,汉密顿抑郁量表(HAMD)评分。结果:Web-ster量表评分显示普拉克索组有效率74.3%,金刚烷胺组有效率51.4%,HAMD量表评分比较,普拉克索组有效率69.2%,金刚烷胺组有效率20.0%。结论:普拉克索对早期帕金森病的运动症状及抑郁状态有良好疗效。
Objective: To observe the efficacy of pramipexole in the treatment of early Parkinson’s disease. Methods: 70 patients with early Parkinson’s disease were randomly divided into pramipexole group 35 cases, amantadine group 35 cases for 12 weeks. A modified Webster score and a HAMD score were used before and after treatment. Results: The Web-ster scale showed an effective rate of 74.3% in the pramipexole group and 51.4% in the amantadine group. The HAMD scale score was 69.2% in the pramipexole group and 20.0% in the amantadine group . Conclusions: Pramipexole has a good effect on motor symptoms and depression of early Parkinson’s disease.