论文部分内容阅读
[目的]观察在使用胰岛素治疗的2型糖尿病患者联合用二甲双胍或单独使用胰岛素治疗的疗效。[方法]选择50例需进行胰岛素治疗的2型糖尿病患者,随机分为胰岛素组(单用胰岛素治疗)和联合组(胰岛素联合二甲双胍治疗),比较两组治疗后空腹血糖(FBG),餐后2h血糖(2hPBG),糖化血红蛋白(HbAlc),体重指数(BMI)的变化及血糖达标时间,每日胰岛素用量的差异。[结果]治疗后两组FBG、2hPBG、HbAIc较治疗前有下降(P﹤0.01),联合组与胰岛素组相比FBG、2hPBG、HbAIc、BMI,血糖达标时间,每日胰岛素用量差异有统计学意义(P﹤0.01)。[结论]在2型糖尿病患者使用胰岛素治疗时,联合二甲双胍治疗可以有效改善胰岛素抵抗,减少体重增加,减少胰岛素用量,缩短血糖达标时间。
[Objective] To observe the curative effect of insulin-treated patients with type 2 diabetes treated with insulin or with metformin alone. [Methods] Fifty patients with type 2 diabetes requiring insulin therapy were randomly divided into insulin group (single insulin treatment) and combination group (insulin plus metformin treatment). The fasting blood glucose (FBG), postprandial 2h blood glucose (2hPBG), glycosylated hemoglobin (HbAlc), body mass index (BMI) changes and blood glucose compliance time, daily differences in insulin dosage. [Results] The FBG, 2hPBG and HbAIc in two groups after treatment were significantly lower than those before treatment (P <0.01). The FBG, 2hPBG, HbAIc, BMI, blood glucose compliance time and daily insulin dosage in the combined group and the insulin group were statistically different Significance (P <0.01). [Conclusion] When type 2 diabetes patients receive insulin therapy, the combination of metformin can effectively improve insulin resistance, reduce weight gain, reduce insulin dosage and shorten blood glucose compliance time.