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目的 探讨维生素E(VE)对新诊 2型糖尿病 (T2DM )患者亚临床动脉粥样硬化 (AS)发生的影响。 方法 选择新诊T2MD患者 85例 ,采用随机数字表法随机分为VE组和对照组 ,1年期间失访 3例 ,实际纳入分析 82例 ,VE组和对照组各 4 1例。两组均采用抗血小板聚集、强化血糖、血压、血脂、体重等综合达标的干预措施 ;VE组加服VE胶囊 2 0 0mg/d ,比较其干预 1年对亚临床AS发生的影响。 结果 两组间年龄、性别、基线体重指数、腰臀比、血脂、血压、2 4h尿白蛋白、胰岛素抵抗指数、高敏C 反应蛋白水平、颈总动脉、股动脉及髂总动脉内中膜厚度 (IMT)等比较均无显著性差异 (P >0 0 5 )。干预 1年后 ,VE组颈总动脉IMT下降幅度大于对照组 (P <0 0 5 ) ,其余上述代谢指标干预 1年下降幅度差异无显著性 (P >0 0 5 )。干预 1年后 ,VE组亚临床AS的发生 (2 6 8% ,11/ 4 1)高于对照组 (7 3% ,3/ 4 1) (P <0 0 5 )。 结论 口服补充VE 1年对采用多因素干预的新诊T2DM患者亚临床AS的发生无保护作用
Objective To investigate the effect of vitamin E (VE) on subclinical atherosclerosis (AS) in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Eighty-five patients with newly diagnosed T2MD were selected and randomly divided into VE group and control group by random number table. Three patients were lost to follow-up in one year. 82 cases were actually included in the analysis, and 41 cases in VE group and control group respectively. The two groups were used anti-platelet aggregation, enhanced blood glucose, blood pressure, blood lipids, body weight and other comprehensive interventions; VE group plus serving VE capsules 200 mg / d, compared its intervention for 1 year on subclinical AS occurrence. Results The results of age, gender, body mass index, waist-hip ratio, blood lipids, blood pressure, 24 h urinary albumin, insulin resistance index, high sensitivity C-reactive protein, carotid artery, femoral artery and common iliac artery (IMT) were no significant difference (P> 0.05). One year after intervention, the decrease of carotid artery IMT in VE group was greater than that in control group (P <0.05). There was no significant difference in the other 1 year after intervention among the above metabolic parameters (P> 0.05). One year after the intervention, the incidence of subclinical AS in the VE group (26.8%, 11/4 1) was higher than that in the control group (73%, 3/4 1) (P <0.05). Conclusions Oral VE supplementation for 1 year has no protective effect on subclinical AS in newly diagnosed T2DM patients treated with multifactorial intervention