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近年来研究证实,食道癌的发生与癌基因被激活,抑癌基因的表达下调或失活,端粒酶的异常表达密切相关。程序性死亡4基因(Pdcd4)是新进发现的一种抑癌基因。现有的对Pd-cd4的研究表明其在人类多种实体肿瘤中的重要作用而备受关注,Pdcd4不仅影响了细胞程序性死亡而且通过抑制蛋白翻译
In recent years, studies have confirmed that the occurrence of esophageal cancer and oncogene is activated, the expression of tumor suppressor gene down or inactivation, the abnormal expression of telomerase is closely related. The programmed death 4 gene (Pdcd4) is a newly discovered tumor suppressor gene. Current research on Pd-cd4 has drawn much attention for its important role in various human solid tumors. Pdcd4 not only affects apoptosis, but also inhibits protein translation