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目的 :探讨老年高血压和冠心病患者的胰岛素抵抗及其与血脂的关系。方法 :以胰岛素曲线下面积 /葡萄糖曲线下面积 (I/ G)和胰岛素抵抗指数作为胰岛素抵抗指标 ,与空腹血脂指标进行直线相关分析。结果 :与正常对照组(n=2 0 )比较 ,高血压组 (n=2 5 )与冠心病组 (n=2 0 )的血清甘油三酯 (TG)、低密度脂蛋白 (L DL- C)、空腹胰岛素、空腹胰岛素 /空腹葡萄糖比值、胰岛素曲线下面积、葡萄糖曲线下面积和 I/ G均显著增加 (P<0 .0 5～ 0 .0 0 1) ,而高密度脂蛋白 (HDL- C)、胰岛素抵抗指数 (I I)显著降低 (P<0 .0 5～ 0 .0 0 1) ,冠心病组改变更显著 ;两组的 I/G与 TG、L DL- C呈正相关 (P<0 .0 5～ 0 .0 1) ,与 HDL- C呈负相关 (P<0 .0 1) ,而 与血脂的的关系则与 I/ G相反。正常对照组则上述指标无相关。结论 :老年高血压和冠心病患者存在胰岛素抵抗 ,它与血脂异常密切相关
Objective: To investigate the relationship between insulin resistance and blood lipid in elderly patients with hypertension and coronary heart disease. Methods: The area under the curve of insulin / area under the curve of glucose (I / G) and insulin resistance index as insulin resistance indicators, and fasting blood lipid indicators were linear correlation analysis. Results Compared with normal control group (n = 20), serum triglyceride (TG), low density lipoprotein (L DL- C), fasting insulin, fasting insulin / fasting glucose, area under the curve of insulin, area under the curve of glucose and I / G increased significantly (P <0.05-0.0.01), while high density lipoprotein HDL-C), insulin resistance index (II) was significantly lower (P <0.05-0.01), coronary heart disease group more significant changes; I / G and TG, L DL-C was positively correlated (P <0.05-0.01), but negatively correlated with HDL-C (P <0.01), while the relationship with serum lipids was opposite to that of I / G. The normal control group is no relevant indicators above. Conclusion: There is insulin resistance in elderly patients with hypertension and coronary heart disease, which is closely related to dyslipidemia