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目的探讨地特胰岛素、甘精胰岛素与中性鱼精蛋白锌胰岛素联合短效胰岛素对2型糖尿病患者的疗效。方法 90例2型糖尿病患者分别应用地特胰岛素、甘精胰岛素与中性鱼精蛋白锌胰岛素联合短效胰岛素治疗,比较3组治疗前后空腹血糖、餐后2h血糖、胰岛素用量及低血糖发生率。结果 3组血糖均下降,但地特胰岛素组降糖效果更明显,且低血糖发生率低。结论与甘精胰岛素、中性鱼精蛋白锌胰岛素相比,地特胰岛素治疗新诊断的2型糖尿病疗效更好,低血糖发生率较低。
Objective To investigate the effect of insulin detemir, insulin glargine and neutral protamine zinc combined with short-acting insulin on type 2 diabetes. Methods Ninety patients with type 2 diabetes were treated with insulin detemir, insulin glargine and insulin protamine combined with short-acting insulin. Fasting plasma glucose, 2-hour postprandial blood glucose, insulin dosage and incidence of hypoglycemia were compared before and after treatment . Results 3 groups of blood glucose decreased, but insulin detemir hypoglycemic effect more obvious, and low incidence of hypoglycemia. Conclusion Detemir insulin treatment of newly diagnosed type 2 diabetes has better efficacy and lower incidence of hypoglycemia than insulin glargine and neutral protamine zinc insulin.